Antidiabetic and Renoprotective Activity of Momordica Dioica in Diabetic Rats
نویسندگان
چکیده
The aim of the present study was to investigate the antidiabetic and renal protective effect of Momordica dioica extract (MDMtE) in streptozotocin-diabetic rats. MDMtE treatment markedly reduced serum glucose, increased serum insulin and urea levels. Study results indicated that the antioxidant enzyme activity of kidney was increased, while thiobarbituric acid reactive substances (TBARS) were reduced in MDMtE treated diabetic rats. Furthermore, histologic observation of kidney of diabetic rats showed degenerative changes in glomerulus and renal tubules and extract treatment rejuvenated kidney histoarchitecture. In conclusion, the present results suggest that MDMtE protects kidney in severe diabetes and thus may provide a promising antidiabetic drug for managing diabetic kidney disorders. INTRODUCTION
منابع مشابه
Beneficial Effects of Different Extracts of Momordica Dioica Seed on Lipid Profile Status in Streptozotocin Induced Diabetic Rats
Diabetes mellitus is one of the widespread and severe metabolic disorders in human all over the world. The present study was designed to evaluate the potential antihyperlipidemic efficacy of chloroform and ethylacetate extracts ofMomordica dioica seeds in diabetic rats. Diabetes was induced by giving Streptozotocin intraperitoneally, rats which showed blood glucose levels of >250 mg/dlwere sele...
متن کاملRenoprotective effect of hydroalcoholic extract of Rheum ribes root in diabetic female rats
Objective: Medical plants, as rich sources of natural antioxidants with antidiabetic effects, are used worldwide to diminish a variety of symptoms and many diseases. R. ribes L., which belongs to the family of polygonaceae, can provide symptomatic relief and assist in the prevention of the secondary complications of the diabetes. Material and Methods: 36 female adult rats were randomly divided ...
متن کاملAntidiabetic and Glycogenesis Effects of Different Fractions of Methanolic Extract of Momordica Charantia (linn.) in Alloxan Induced Diabetic Rats
The study was undertaken to investigate the antihyperglycemic, oral glucose tolerance test (OGTT) and glycogenesis effects of the different fractions (Petroleum ether, ethyl acetate and chloroform) of methanolic extract of Momordica charantia. The different fractions of the extract were administered intraperitoneally as a single dose of 150 mg/kg body weight to alloxan induced as well as glucos...
متن کاملMomordica dioica Roxb. (Spine Gourd): Multiple shoot induction from nodal cultures and its antidiabetic activity
Momordica dioica Roxb. (Spine Gourd) (Cucurbitaceae) is an important vegetable with high food and medicinal value. Maintaining tuber quality in field conditions as well its conservation during storage is difficult. Micropropagation may help to overcome these problems to a great extent. As there is limited information on the above mentioned aspects is not available. Therefore, the present study ...
متن کاملEffectiveness of Antihyperglycemic Effect of Momordica charantia: Implication of T-Cell Cytokines
Background/Objective We investigate the effect of antidiabetic Momordica charantia fruit juice on T cells' differentiation, through plasmatic cytokine quantification in type 1 diabetic rats (T1D). Methods Male Wistar rats were rendered diabetic by the injection of five low doses of streptozotocin. Then, animals were treated with Momordica charantia fruit juice for 28 consecutive days. Plasmat...
متن کامل